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Undiagnosed immune deficiency rising among Indian children: Doctors

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New Delhi, April 28 (IANS) Undiagnosed immune deficiency is significantly rising among children under the age of five in India, said doctors here on Sunday, as part of the World Primary Immunodeficiency Week.

Every year, April 22 to 29 is observed as World Primary Immunodeficiency Week. It aims to raise awareness about Primary immunodeficiencies (PIs), also known as inborn errors of immunity (IEI) — a group of 450 rare and chronic conditions where a part of the body’s immune system is missing or does not function correctly.

Dr Gaurav Kharya, Director, Department of Bone Marrow Transplant and Cellular Therapy, Indraprastha Apollo Hospital, New Delhi, told IANS that the prevalence of primary immunodeficiency disorders (PIDs) is rising in India.

“These are potentially fatal genetic conditions that affect a child’s immune system, making them more susceptible to infections, autoimmunity, and malignancies,” he explained.

While there is no nationwide data on the prevalence of PIDs in India, statistical projections claim that there could be more than one million patients with PIDs in the country.

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Dr Sagar Bhattad, Consultant – Paediatric Immunology & Rheumatology, Aster CMI Hospital, Bangalore, told IANS that over the past seven years, the hospital has identified more than 450 children suffering from rare and complex immune deficiency diseases.

“Whereas, a decade ago, the number was limited to 1-2 cases per month, which has now increased to 10-12 every month — a significant five-fold increase. In the past year alone, over 125 diagnoses were made, and experts predict this number to rise substantially in the coming years.

“It is estimated that before 2004, less than 50 cases of immune deficiency were identified nationally. This number has risen dramatically, with an estimated 300-500 cases diagnosed in 2014 and a further increase to 2,500-3,000 cases projected in 2024. This represents a staggering 300-400 per cent increase over the past decade,” Dr Sagar said.

The doctors blame lack of awareness about the conditions as well as treatment facilities to be a major reason for the rise in PIDs.

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“These genetic conditions are more common in communities that practise consanguineous marriages. Many cases of immunodeficiency go undiagnosed due to a lack of facilities and awareness, especially in rural areas,” Dr Gaurav said.

“The lack of awareness and diagnostic facilities are often the reasons why these patients do not reach tertiary care centres where they can be treated for these disorders,” he explained.

The doctors stressed the need for recognising the signs and symptoms that can help in early diagnosis, as well as better outcomes. Genetic testing during pregnancy can be key to identifying potential problems and preventing recurrence in future pregnancies.

According to Dr Gaurav, bone marrow transplant (BMT), which replaces the defective immune cells of the patient with healthy cells from a compatible donor, has emerged as a potentially curative treatment for several types of primary immunodeficiencies.

“If a child falls ill repeatedly and requires frequent antibiotics, it could be a sign of a serious genetic immune problem. These conditions can affect multiple children in the same family,” Dr Sagar said.

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“By identifying these conditions at early stages, children can receive the targeted treatment they need to avoid frequent infections and the overuse of antibiotics,” he said, calling for a wider availability of affordable genetic testing to enable earlier diagnoses and improve treatment outcomes.

“By working together, we can ensure that no child misses out on a healthy life due to an undiagnosed immune deficiency,” the doctor said.

–IANS

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As Maha detects 91 FLiRT Covid cases, expert rules out any immediate concern

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New Delhi, May 12 (IANS) Even as the 91 cases of new FLiRT Covid-19 variants, accounting for more than a third of cases in the US, have reportedly been detected in Maharashtra, there is nothing to worry immediately, a top expert said on Sunday.

The new set of variants dubbed FLiRT, majorly includes KP.1.1, and KP.2 strains. These are named based on the technical names for their mutations, one of which includes the letters “F” and “L”, and another of which includes the letters “R” and “T”.

Genome sequencing of March and April showed that Maharashtra has 91 cases of KP.2 — Pune (51), Thane (20), Amravati (7) Aurangabad (7), Solapur (2), Ahmednagar (1), Nashik (1), Latur (1), and Sangli (1).

“What we see now, is the result of genome sequencing of the last two months, that is March and April. So, there is no cause of concern immediately as out of the 91 cases, not a single death, hospitalisation, or severe disease has been reported,” infectious disease expert Dr Ishwar Gilada, told IANS.

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“Even the test positivity rate is around 1 per cent,” he added.

Dr Rajesh Karyakarte, Maharashtra’s genome sequencing coordinator, said that KP.2 has become the predominant Covid strain in the state.

However, there hasn’t been a corresponding increase in hospitalisations or severe cases, The Times of India reported.

FLiRT variants come from the lineage of the highly transmissible and immune system-evading Omicron.

First identified globally in January, KP.2 is a descendant of Omicron’s JN.1. According to the data from the US Centers for Disease Control and Prevention, KP.2 accounted for about one in four or 25 per cent of new sequenced cases in the country in the last weeks of April.

Similar to previous variants, the symptoms typically include a sore throat, runny nose, congestion, tiredness, fever (with or without chills), headache, muscle pain, and sometimes loss of taste or smell.

“Covid has not gone away, but it is not creating any havoc. It is not creating any hospitalisation or deaths, and it is much milder than the flu. So, it should not be considered a separate disease. It should be considered like the flu and we can call it Covi-flu,” said Dr Gilada, Consultant in Infectious Diseases Unison Medicare and Research Centre, Mumbai.

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However, he called for proper whole genome sequencing.

“Though the variant will become prominent in numbers, it is not causing a surge in demand for oxygen, beds, ICUs, or ventilators, and there are also no deaths. “So, I think we should not be worried and concentrate on other emerging health problems,” he said.

–IANS

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'Anaemia a preventable health threat in girls, women in India'

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New Delhi, May 12 (IANS) Anaemia is a very common yet preventable threat among girls and women in India, said health experts on Sunday.

A deficiency of healthy red blood cells or haemoglobin needed to carry oxygen to the body’s tissues raises the risk of anaemia. The condition is more common among women and girls. Lack of a proper iron-rich diet, particularly among women in their reproductive age can result in tiredness, weakness, and shortness of breath, the experts noted.

According to the National Family Health Survey 5 (NFHS-5, 2019-21), 25 per cent of men (aged 15-49 years) and 57 per cent of women (aged 15-49 years) suffer from anaemia.

“Anaemia is a very common and another rampant problem in Indian ladies, especially, due to intake of a diet low in iron and sometimes, it is genetically determined also. A vegetarian diet is quite low in iron and hence, supplements are necessary,” Dr M. Wali, Senior Consultant, Department of Medicine, Sir Ganga Ram Hospital told IANS.

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“Pregnancy increases the requirement of iron and also lactation, so these two conditions are particular to the females,” he added.

The doctor further noted that anaemia is prevalent in both rural and urban women in India.

“Most Indian urban women who are dieting to reduce weight become deficient and rural women because of hard work, increased requirements, increased loss of the menstrual blood due to infection or otherwise repeated childbirth, so all these causes lead to lack of blood or anaemia,” Dr Wali said.

The NFHS- data shows that anaemia is also highly prevalent among young adolescent boys (31 per cent), and adolescent girls (59 per cent) aged between 15 and 19 years, as well as in pregnant women (52.2 per cent) between 15 and 49 years, and also in small children (67 per cent) aged between 6 months and below 5 years.

Common indicators of anaemia include fatigue, pale complexion, breathlessness, dizziness, and cold extremities.

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“Anaemia poses a significant health challenge in India, especially for women as they are more prone to lower haemoglobin levels owing to their distinct physiological requirements, including menstrual and pregnancy-related blood loss,” Dr Rahul Bhargava, Principal Director & Chief BMT, Fortis Memorial Research Institute, Gurugram, told IANS.

Importantly, the health experts pointed out that the condition progresses slowly and discreetly, and is difficult to detect. The symptoms also tend to appear late. They advised eating foods rich in iron or taking supplements.

“Anaemia is very difficult to detect, most of the time it is slowly developing. Symptoms like breathlessness (an important symptom), chest pain (sometimes mistaken as heart pain), difficulty in pregnancy, palpitation, headache, and easy fatigability appear very late,” Dr Wali said.

“Many women quietly battle anaemia — a preventable threat in India. By promoting a balanced diet rich in iron, advocating for accessible iron supplements available through government systems, and emphasising regular screening, we can empower women to combat anaemia and embrace healthier lives together,” Dr Ameet Babre, National Programme Manager at Nutrition International, told IANS.

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The most effective preventive measures against anaemia involve adopting an iron-rich diet, which includes lean meats, poultry, fish, legumes, tofu, leafy greens like spinach and kale, fortified cereals, and nuts, Dr Bhargava said.

Fruits like guava, banana, figs, and pomegranate may also help combat anaemia.

–IANS

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89 pc Indian mothers concerned about kids' screen time

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New Delhi, May 12 (IANS) A whopping 89 per cent of Indian mothers are concerned about the screen time of their children, according to a report on Sunday.

The report, released by market research firm Techarc on Mother’s Day, is based on a survey of 600 working mothers, across four metro cities, having at least one child between grade 3-10 in school.

It explores insights on the digital ecosystem in which mothers operate today viz-a-viz the challenges, concerns, interests, and preferences.

“Mothers believe that increased screen time affects their studies and has a negative impact on the mental and physical health of their children,” the report said.

Further, the report showed that privacy (81 per cent), inappropriate content (72 per cent), teenage influencers (45 per cent), deep fakes, and impersonation (26 per cent) were other top concerns bothering mothers.

Mothers feel that deep fakes and Gen AI will add to their future parenting worries as they get to see the rising cases along with learning how these can be negatively used to malign the reputation and credibility of individuals.

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Among the devices, mothers are concerned about the expected popularity of VR headsets, especially after the launch of Apple Vision Pro.

Mothers believe that “this form factor will zone out their children who will lose attentiveness towards the environment adding to their distractions,” the report said.

On the other hand, mothers also found the digital world much more useful and relevant for children, compared to five years ago.

More than 60 per cent of the mothers spent 51-85 per cent on their children through digital mediums buying various goods and services. Nearly 20 per cent of digital savvy mothers spent more than 85 per cent, the report said.

Mothers’ most trusted digital partners include Amazon (for shopping), Swiggy (for food), and Disney Hotstar (for entertainment)

–IANS

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More than 1 in 5 new mothers experience postpartum depression: Doctors

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New Delhi, May 12 (IANS) While parenthood comes as a blessing for many, for more than 20 per cent of mothers, the new chapter of life creates stress, anxiety and postpartum depression, which can turn fatal for both the mother and child, without adequate support, said doctors on Mother’s Day on Sunday.

Mother’s Day is celebrated every year on the second Sunday of May.

Postpartum depression is common but a treatable medical condition that many women face after childbirth. While the exact cause can be difficult to identify, several factors contribute to these feelings of sadness, anxiety, and tiredness.

These can result from genetics, hormonal changes, sleep deprivation, fatigue, or the pressure of becoming a mother.

The overall pooled estimate of the prevalence of postpartum depression was 22 per cent reporting postpartum depression within two weeks of delivery.

“The journey to parenthood presents couples with a myriad of challenges, often impacting their emotional well-being profoundly. The complexities surrounding late pregnancies, assisted conception methods like IVF, and the burden of preterm deliveries weigh heavily on maternal mental health,” Dr Saurabh Mehrotra, Associate Director, Psychiatry, Institute of Neurosciences, Medanta, Gurugram, told IANS.

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Studies reveal that maternal mental illness during pregnancy correlates with adverse outcomes for both mother and child, including preterm delivery and poor neurodevelopment.

“At Medanta, we witness approximately 70-80 per cent of mothers having post-partum blues out of which 20 per cent of mothers with postpartum depression grapple with such mental health challenges, emphasising the critical need for comprehensive emotional support and holistic care throughout the perinatal period,” Dr Saurabh said.

The symptoms of postpartum depression include insomnia, loss of appetite, intense irritability, and even difficulty bonding with the baby. For mothers facing the postpartum blues, asking for help may be one of the most crucial steps, as it may help them easily bond with the baby, the experts said.

But, “if left untreated, the condition can last several months or longer,” Dr Teji Dawane, Senior Consultant, Obstetrician and Gynaecologist, Motherhood Hospitals, Whitefield, Bengaluru, told IANS.

“One of the first steps in addressing postpartum depression is early detection through screenings during prenatal and postnatal care and giving importance to emotional well-being. It is also encouraged to seek help from professional support services such as counselling and therapy,” Dr Teji said.

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Sometimes, treatment options also include medication like antidepressants to manage symptoms effectively. It is equally important to create a supportive family environment and develop self-care practices for new parents, the experts noted.

–IANS

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Premature menopause may raise risk of early death: Study

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New Delhi, May 12 (IANS) Women who enter menopause before the age of 40 are more likely to die young, finds a study.

The study presented at the 26th European Congress of Endocrinology in Sweden, however, showed that the risk can be lowered with hormone replacement therapy (HRT) — the most common treatment.

While most women experience menopause between the ages of 45 and 55, about 1 per cent experience menopause before the age of 40 years, known as premature menopause or premature ovarian insufficiency (POI). It increases the risk of long-term health problems such as heart disease.

The reason behind this remains largely unknown but can be brought on spontaneously or by some medical treatments such as chemotherapy or by surgically removing the ovaries.

The team from the University of Oulu, in Finland, examined 5,817 women who were diagnosed with spontaneous or surgical premature ovarian insufficiency in Finland, between 1988 and 2017, and compared them with 22,859 women without POI.

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The results revealed spontaneous premature ovarian insufficiency more than twice raised the risk of dying of any cause or heart disease, and more than four times from cancer.

On the other hand, the risk of all-cause and cancer mortality halved in women who used HRT drugs for more than six months. Further, women with early menopause from surgery were not found to have any added mortality risk.

“Our findings suggest specific attention should be paid to the health of women with spontaneous premature ovarian insufficiency to decrease excess mortality,” said Hilla Haapakoski, a doctoral student at the University of Oulu, in Finland.

–IANS

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